Methyl 2-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)acetate → {2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-4-methoxy-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

HRID 563770Notes

Reaction equation

HRID 563770 reaction equation
[CH3:1][O:2][C:3](=[O:22])[CH2:4][C:5]1[CH:10]=[C:9](B2OC(C)(C)C(C)(C)O2)[CH:8]=[CH:7][C:6]=1[O:20][CH3:21].[CH2:23]([O:30][C:31](=[O:47])[N:32]([CH2:35][C:36]1[CH:41]=[C:40]([C:42]([F:45])([F:44])[F:43])[CH:39]=[CH:38][C:37]=1Br)[CH2:33][CH3:34])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH3:1][O:2][C:3](=[O:22])[CH2:4][C:5]1[CH:10]=[C:9]([C:37]2[CH:38]=[CH:39][C:40]([C:42]([F:43])([F:44])[F:45])=[CH:41][C:36]=2[CH2:35][N:32]([C:31]([O:30][CH2:23][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)=[O:47])[CH2:33][CH3:34])[CH:8]=[CH:7][C:6]=1[O:20][CH3:21]

Participants

3

Reactant 2

HCID 22930398Methyl 2-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)acetateHCID 66604198(2-Bromo-5-trifluoromethyl-benzyl)-ethyl-carbamic acid benzyl ester

Product 1

HCID 66608296{2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-4-methoxy-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: [2-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid methyl ester and (2-bromo-5-trifluoromethyl-benzyl)-ethyl-carbamic acid benzyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-aca4c076949c4365a4b4843abd929edc
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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