(5-Benzyloxy-2-chloro-phenyl)-acetic acid ethyl ester → (2-Chloro-5-hydroxy-phenyl)-acetic acid ethyl ester

HRID 563773Notes

Reaction equation

HRID 563773 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[C:10]([O:12]CC2C=CC=CC=2)[CH:9]=[CH:8][C:7]=1[Cl:20])[CH3:2]>CCO>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[C:10]([OH:12])[CH:9]=[CH:8][C:7]=1[Cl:20])[CH3:2]

Participants

3

Reactant 1

HCID 58148945(5-Benzyloxy-2-chloro-phenyl)-acetic acid ethyl ester

Product 1

HCID 57966617(2-Chloro-5-hydroxy-phenyl)-acetic acid ethyl ester

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

(5-Benzyloxy-2-chloro-phenyl)-acetic acid ethyl ester (1.7 g, 5.6 mmol) was dissolved in EtOH (30 mL) and degassed with N2. 5% Palladium on carbon (1 g) was added, and the reaction was purged with H2 and then stirred under an H2 balloon at 50° C. overnight. The mixture was filtered and concentrated to give the title compound.

Workup

  1. customdegassed with N2
  2. addition5% Palladium on carbon (1 g) was added
  3. customthe reaction was purged with H2
  4. filtrationThe mixture was filtered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-c6b1d07f8696411ba52af3a4844a4fc9
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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