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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 563785Generated: October 25, 2026

5-Bromo-2-fluorobenzaldehyde → (5-Bromo-2-fluorophenyl)methanol

https://huagongshe.com/reaction/563785

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromo-2-fluorobenzaldehydeHCID 736327—
ReactantSodium borohydrideHCID 4311764—
SolventMethanolHCID 887—
Product(5-Bromo-2-fluorophenyl)methanolHCID 2773352—

Reaction Steps

To a solution of 5-bromo-2-fluorobenzaldehyde (1.3 g, 6.4 mmol) in MeOH (10 mL) was added sodium borohydride (0.29 g, 7.7 mmol), and the reaction was stirred at room temperature for 5 minutes. After aqueous work-up, the residue was purified by silica gel chromatography to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08067445B2
Source datasetuspto-grants-2011_11
ORD IDord-e013470df19541eaa101c5ba8cb8d399
Source noteuspto-grants-2011_11