HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 563787Generated: October 27, 2026
Water → 2-(5-Bromo-2-fluorophenyl)acetonitrile
https://huagongshe.com/reaction/563787
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 4-Bromo-2-(bromomethyl)-1-fluorobenzene | HCID 13553295 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-(5-Bromo-2-fluorophenyl)acetonitrile | HCID 23509631 | — |
Reaction Steps
4-Bromo-2-bromomethyl-1-fluoro-benzene (1.2 g, 3.7 mmol) and sodium cyanide (2.0 g, 4.1 mmol) were combined in DMSO (15 mL) and stirred at 90° C. for 2 hours. Once no starting material was seen by analytical tlc, the mixture was worked-up with EtOAc and H2O to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08067445B2 |
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| Source dataset | uspto-grants-2011_11 |
|---|
| ORD ID | ord-d5aa4535bafa47a2ac585db95af5ff5a |
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| Source note | uspto-grants-2011_11 |
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