(Ethyl)[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethylbenzyl]carbamic acid benzyl ester → {2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-5,4'-bis-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

HRID 563803Notes

Reaction equation

HRID 563803 reaction equation
[CH2:1]([O:8][C:9](=[O:33])[N:10]([CH2:31][CH3:32])[CH2:11][C:12]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:13]=1B1OC(C)(C)C(C)(C)O1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:34][O:35][C:36](=[O:56])[CH2:37][C:38]1[CH:43]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:41]=[C:40](OS(C(F)(F)F)(=O)=O)[CH:39]=1>>[CH3:34][O:35][C:36](=[O:56])[CH2:37][C:38]1[CH:39]=[C:40]([C:13]2[CH:14]=[CH:15][C:16]([C:18]([F:19])([F:20])[F:21])=[CH:17][C:12]=2[CH2:11][N:10]([C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[O:33])[CH2:31][CH3:32])[CH:41]=[C:42]([C:44]([F:46])([F:45])[F:47])[CH:43]=1

Participants

3

Reactant 2

HCID 66603618(Ethyl)[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethylbenzyl]carbamic acid benzyl esterHCID 86651106HCID 86651106, compound

Product 1

HCID 86651132{2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-5,4'-bis-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: ethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-carbamic acid benzyl ester and (3-trifluoromethanesulfonyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-40cf5a44bb9946e79b01fb38c26c82f9
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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