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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 563808Generated: November 2, 2026

Methyl 2-(3-bromo-5-chlorophenyl)acetate → (5-Chloro-2'-{[ethyl-(4-fluoro-benzyloxycarbonyl)-amino]-methyl}-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

https://huagongshe.com/reaction/563808

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-(3-bromo-5-chlorophenyl)acetateHCID 58149292—
ReactantEthyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-carbamic acid 4-fluoro-benzyl esterHCID 66607601—
Product(5-Chloro-2'-{[ethyl-(4-fluoro-benzyloxycarbonyl)-amino]-methyl}-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl esterHCID 66607076—

Reaction Steps

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: ethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-carbamic acid 4-fluoro-benzyl ester and (3-bromo-5-chloro-phenyl)-acetic acid methyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08067445B2
Source datasetuspto-grants-2011_11
ORD IDord-c83f2a1dc05340ef970854e91d34d75f
Source noteuspto-grants-2011_11