Methyl 2-(3-bromo-5-chlorophenyl)acetate → [5-Chloro-2'-(1-ethyl-3-methyl-ureidomethyl)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid methyl ester

HRID 563814Notes

Reaction equation

HRID 563814 reaction equation
[CH2:1]([N:3]([CH2:8][C:9]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:10]=1B1OC(C)(C)C(C)(C)O1)[C:4]([NH:6][CH3:7])=[O:5])[CH3:2].[CH3:28][O:29][C:30](=[O:40])[CH2:31][C:32]1[CH:37]=[C:36]([Cl:38])[CH:35]=[C:34](Br)[CH:33]=1>>[CH3:28][O:29][C:30](=[O:40])[CH2:31][C:32]1[CH:33]=[C:34]([C:10]2[CH:11]=[CH:12][C:13]([C:15]([F:16])([F:17])[F:18])=[CH:14][C:9]=2[CH2:8][N:3]([CH2:1][CH3:2])[C:4]([NH:6][CH3:7])=[O:5])[CH:35]=[C:36]([Cl:38])[CH:37]=1

Participants

3

Reactant 2

HCID 58149292Methyl 2-(3-bromo-5-chlorophenyl)acetateHCID 666071381-Ethyl-3-methyl-1-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-urea

Product 1

HCID 66607666[5-Chloro-2'-(1-ethyl-3-methyl-ureidomethyl)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: 1-ethyl-3-methyl-1-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-urea and (3-bromo-5-chloro-phenyl)-acetic acid methyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a793551d57c3482a8006a3c2bdf4424a
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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