Methyl 2-(3-bromo-5-chlorophenyl)acetate → {2'-[(Benzoyl-ethyl-amino)-methyl]-5-chloro-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

HRID 563816Notes

Reaction equation

HRID 563816 reaction equation
[CH2:1]([N:3]([CH2:12][C:13]1[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:15][C:14]=1B1OC(C)(C)C(C)(C)O1)[C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:2].[CH3:32][O:33][C:34](=[O:44])[CH2:35][C:36]1[CH:41]=[C:40]([Cl:42])[CH:39]=[C:38](Br)[CH:37]=1>>[CH3:32][O:33][C:34](=[O:44])[CH2:35][C:36]1[CH:37]=[C:38]([C:14]2[CH:15]=[CH:16][C:17]([C:19]([F:21])([F:22])[F:20])=[CH:18][C:13]=2[CH2:12][N:3]([C:4](=[O:11])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:1][CH3:2])[CH:39]=[C:40]([Cl:42])[CH:41]=1

Participants

3

Reactant 2

HCID 58149292Methyl 2-(3-bromo-5-chlorophenyl)acetateHCID 66607577N-ethyl-N-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-benzamide

Product 1

HCID 66607292{2'-[(Benzoyl-ethyl-amino)-methyl]-5-chloro-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: N-ethyl-N-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-benzamide and (3-bromo-5-chloro-phenyl)-acetic acid methyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-36e10cd38d894f3ea0faa7cb63071eb8
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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