Methyl iodide → HCID 66607155, compound

Participants

Reaction Steps

To a solution of {2′-[(acetyl-ethyl-amino)-methyl]-5-chloro-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid ethyl ester (0.070 g, 0.17 mmol) in THF at −78° C. under N2 was added sodium hexamethyldisilazide (1 M in THF; 0.20 mL, 0.20 mmol), and the mixture was stirred for 5 minutes. Iodomethane (0.01 mL, 0.20 mmol) was then added, and the reaction was stirred at −78° C. for 30 minutes. Once no starting material was seen by analytical LCMS, the mixture was worked-up with EtOAc and H2O, and the crude material was purified by silica gel chromatography to give the title compound.

Provenance & Evidence