Hydrazine hydrate (1:1) → HCID 57507187, compound

Participants

Reaction Steps

To a solution of (4-chloro-6-morpholin-4-yl-1,3,5-triazin-2-yl)-(4-trifluoromethoxyphenyl)amine (XIV) (3.0 g, 8.51 mmol) in dioxane (16 mL) was added hydrazine hydrate (2 mL) and the mixture stirred at ambient temperature for 30 min. The mixture was diluted with water and the resulting slurry stirred for 10 min and filtered under vacuum. The white precipitate was washed with copious amount of water and dried under vacuum to give (4-hydrazino-6-morpholin-4-yl-1,3,5-triazin-2-yl)-(4-trifluoromethoxyphenyl)amine (XV) (3.01 g, 95% yield): 1H NMR (CDCl3) δ 7.55 (d, J=8.4 Hz, 2H), 7.13 (d, J=8.4 Hz, 2H), 3.74-3.87 (m, 8H); ESI/MS 372 (M+H), 370 (M−H).

Provenance & Evidence