(S)-2-Phenoxypropionic acid → (R)-2-[3-(Diisopropylamino)-1-phenylpropyl]-4-(2-hydroxyethyl)phenol (S)-2-phenoxypropionic acid salt

Participants

Reaction Conditions

Reaction Steps

(S)-2-Phenoxypropionic acid (3.40 g, 20.5 mmol, 1 equiv) was added to a solution of 2-[3-(diisopropylamino)-1-phenylpropyl]-4-(2-hydroxyethyl)phenol (Example 9, 7.28 g, 20.5 mmol, 1 equiv) in ethyl acetate. The mixture was heated at 80° C. for 2 days, upon which the mixture was cooled to room temperature, filtered and washed with ethyl acetate and dried in vacuo at 50° C. overnight to give the title compound as a white solid (3.9 g, 7.48 mmol, 37% yield, 94% ee).

Provenance & Evidence