Chlorosuccinimide → 2-chloro-2-methylthio-N-(2-methylpent-3-yn-2-yl)acetamide

Participants

Reaction Conditions

Reaction Steps

The product of Step 1 (0.824 g) was dissolved in carbon tetrachloride (15 ml) with warming. The solution was then cooled to 0° C. and N-chlorosuccinimide (NCS, 0.653 g) was then gradually added and the mixture was stirred at ambient temperature for 2 hours. The reaction mixture was filtered to remove succinimide and the resulting liquid was evaporated to give 2-(chloro)-2-(methylthio)-N-(2-methylpent-3-yn-2-yl) acetamide as a clear oil (1.4 g), which was used without further purification.

Provenance & Evidence