反应详情

温度

180 °C

6-Amino-3,8-dibromoquinoline (1.1 g) was suspended in phosphoric acid (10 ml) containing water (10 ml) and heated in a sealed glass tube at 180° C. for 4 days. The mixture was cooled to ambient temperature, poured into brine and extracted with ethyl acetate. The organic extract was dried over magnesium sulphate, evaporated under reduced pressure and the residual solid fractionated by chromatography (silica; hexane/ethyl acetate) to give 3,8-dibromo-6-hydroxy-quinoline, 0.4 g, as a pale brown solid.

1. temperatureThe mixture was cooled to ambient temperature
2. extractionextracted with ethyl acetate
3. extractionThe organic extract
4. dry with materialwas dried over magnesium sulphate
5. customevaporated under reduced pressure