2-Bromo-N-methyl-2-phenylacetamide → 2-{4-[2-(4-Methoxy-phenyl)-ethyl]-2,3-dimethyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl}-N-methyl-2-phenyl-acetamide

HRID 563929Notes

Reaction equation

HRID 563929 reaction equation
Br[CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([NH:5][CH3:6])=[O:4].[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH:23]2[C:28]3[C:29]([CH3:33])=[C:30]([CH3:32])[S:31][C:27]=3[CH2:26][CH2:25][NH:24]2)=[CH:17][CH:16]=1>>[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH:23]2[C:28]3[C:29]([CH3:33])=[C:30]([CH3:32])[S:31][C:27]=3[CH2:26][CH2:25][N:24]2[CH:2]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]([NH:5][CH3:6])=[O:4])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 124711602-Bromo-N-methyl-2-phenylacetamideHCID 598200104-[2-(4-Methoxy-phenyl)-ethyl]-2,3-dimethyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine

Product 1

HCID 249703022-{4-[2-(4-Methoxy-phenyl)-ethyl]-2,3-dimethyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl}-N-methyl-2-phenyl-acetamide

Procedure

(MS(m/e): 449.1 (MH+)), were prepared from 2-bromo-N-methyl-2-phenyl-acetamide (commercially available) and 4-[2-(4-methoxy-phenyl)-ethyl]-2,3-dimethyl-4,5,6,7-tetrahydro-thieno [3,2-c]pyridine both as light brown solid.

Sources & evidence

ORD record
ord-18a21c55dee94d2b8a01619e5c456786
Source dataset
uspto-grants-2011_11
Patent number
US08067598B2

Reaction notes

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