HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopropane → HCID 9996100, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopropane | HCID 6358 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 11708908 | HCID 11708908 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 9996100 | HCID 9996100 | 7.3% |
Reaction Steps
In analogy to example 1, (1H-benzoimidazol-2-yl)(2,6-dichlorophenyl)amine (250 mg) was dissolved in dimethylformamide (3 ml), deprotonated with sodium hydride (43 mg) and alkylated with isopropyl bromide (111 mg) in a closed vessel at 100° C. for one hour. Workup and chromatography resulted in 21 mg of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067614B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-2181a9fd3e3b435fbff17b105da0614f |
| Source note | uspto-grants-2011_11 |