HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromocyclopentane → HCID 10450299, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromocyclopentane | HCID 8728 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 11708908 | HCID 11708908 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 10450299 | HCID 10450299 | 12.2% |
Reaction Steps
In analogy to example 1, (1H-benzoimidazol-2-yl)(2,6-dichlorophenyl)amine (250 mg) was dissolved in dimethylformamide (2 ml) at room temperature, deprotonated with sodium hydride (48 mg) and alkylated with cyclopentyl bromide (136.7 mg) in a closed vessel at 100° C. for 8 h. Workup and chromatography resulted in 38 mg of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067614B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-40060c54320f49b7a454d0bfc82aba35 |
| Source note | uspto-grants-2011_11 |