HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Methyl[5-(4-chlorophenyl)-3-methyl-1-(3-methylisothiazol-5-yl)-1h-pyrazol-4-yl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | (3-Methyl-isothiazol-5-yl)-hydrazine | HCID 55282001 | — |
| Reactant | Methyl 3-[(4-chlorophenyl)carbonyl]-4-oxopentanoate | HCID 67004944 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl[5-(4-chlorophenyl)-3-methyl-1-(3-methylisothiazol-5-yl)-1h-pyrazol-4-yl]acetate | HCID 131729291 | — |
Reaction Steps
0.301 g (2.0 mmol) of 5-hydrazinyl-3-methylisothiazole and 0.099 ml (2.0 mmol) of concentrated sulfuric acid were added to 0.500 g (2.0 mmol) of methyl 3-[(4-chlorophenyl)carbonyl]-4-oxopentanoate in 10.00 ml of methanol, and the mixture was stirred under reflux for 6 hours. The mixture was poured into water and extracted with ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067611B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-1fca7c035105413ebe12f970b69db05f |
| Source note | uspto-grants-2011_11 |