HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Nitro-7-azaindole → 1H-pyrrolo(2,3-b)pyridin-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Nitro-7-azaindole | HCID 11521140 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1H-pyrrolo(2,3-b)pyridin-5-amine | HCID 11715187 | — |
Reaction Steps
2.675 g 5-Nitro-1H-pyrrolo[2,3-b]pyridine in 200 ml THF were hydrogenated over 1.0 g Platinum on carbon at atmospheric pressure for 3 hrs at RT (with thin layer chromatography (TLC) control). The catalyst was removed by filtration, the filtrate was evaporated and the residue purified by chromatography on silica in ethyl acetate/heptane mixtures.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067599B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-7f1366378be44d9d91a055965122cfd7 |
| Source note | uspto-grants-2011_11 |