反应详情

1.87 g 1H-Pyrrolo[2,3-b]pyridin-5-ylamine in 60 ml dry pyridine were treated dropwise at RT with a solution of 6.79 g 2-chloro-5-nitrobenzoyl chloride in 10 ml dichloromethane. Stirring was continued over night. The mixture was evaporated and the residue was treated with 25 ml methanol and 10 ml conc. ammonia for 2 hrs at RT. The solvents are again evaporated and the residue is dispersed in water. The crude product is isolated by filtration and washed thoroughly with water and diethylether.

1. waitwas continued over night
2. customThe mixture was evaporated
3. additionthe residue was treated with 25 ml methanol and 10 ml conc. ammonia for 2 hrs at RT
4. customThe solvents are again evaporated
5. additionthe residue is dispersed in water