HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Ethyl 3-(2-cyanopropan-2-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Ethyl 3-(1-cyanoethyl)benzoate | HCID 67007698 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 3-(2-cyanopropan-2-yl)benzoate | HCID 67008001 | — |
Reaction Steps
3-(1-Cyano-ethyl)-benzoic acid ethyl ester were dissolved in 4 ml dry DMF. Under nitrogen atmosphere, 138 mg of 60% sodium hydride and 423 mg methyl iodide were added at RT. The mixture was stirred for 16 hrs, then quenched by addition of 1 ml methanol and evaporated. The residue was purified by chromatography on silica in ethyl acetate/heptane mixtures.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067599B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-9eac2464aca445b09a7c7c939b5548e1 |
| Source note | uspto-grants-2011_11 |