Potassium Carbonate → HCID 67008007, compound

Participants

Reaction Steps

To a solution of 2-methyl-4-nitrobenzoic acid (2 g, 11 mmol) in benzene (40 ml) was added thionyl chloride (2 ml) and refluxed for 3 h. The reaction mixture was concentrated, diluted with dry acetonitrile (20 ml). To this solution was added dry K2CO3 (2 g, 14 mmol) followed by a solution of 1H-Pyrrolo[2,3-b]pyridin-5-ylamine (example c), 1.4 g, 11 mmol) in acetonitrile (20 ml) and the reaction mixture and stirred for 16 h at RT. Solvent was removed under reduced pressure, diluted with water stirred for 15 min and filtered. The solid residue was washed with EtOAc to get 2.4 g of crude title product. LC-MS: (m/z 297)

Provenance & Evidence