反应详情

To 10.0 g (29.8 mmol) 4-benzyloxy-1-[2-(4-hydroxymethyl-phenyl)-ethyl]-1H-pyridin-2-one (preparation 2a) in 150 mL MeOH is added 1.50 g Rh/C. The reaction mixture is stirred under a hydrogen atmosphere of 3000 hPa at RT for 20 h. 300 mL MeOH is added and the mixture is heated to reflux. The catalyst is removed by filtration and the solvent is removed almost completely. After cooling to RT, the precipitate is collected and dried in vacuo at 40° C.

1. temperaturethe mixture is heated to reflux
2. customThe catalyst is removed by filtration
3. customthe solvent is removed almost completely
4. temperatureAfter cooling to RT
5. customthe precipitate is collected
6. customdried in vacuo at 40° C.