4-Benzyloxy-1-[2-(4-hydroxymethyl-phenyl)-ethyl]-1H-pyridin-2-one → 4-Hydroxy-1-[2-(4-hydroxymethyl-phenyl)-ethyl]-1H-pyridin-2-one

HRID 564041노트

반응식

HRID 564041 반응식
C([O:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][OH:24])=[CH:19][CH:18]=2)[C:11](=[O:25])[CH:10]=1)C1C=CC=CC=1>CO.[Rh]>[OH:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][OH:24])=[CH:19][CH:18]=2)[C:11](=[O:25])[CH:10]=1

참가 물질

4

반응물 1

HCID 670067844-Benzyloxy-1-[2-(4-hydroxymethyl-phenyl)-ethyl]-1H-pyridin-2-one

생성물 1

HCID 580427304-Hydroxy-1-[2-(4-hydroxymethyl-phenyl)-ethyl]-1H-pyridin-2-one

시약·촉매·용매 2

HCID 23948Rhodium촉매HCID 887Methanol용매2회

실험 절차

To 10.0 g (29.8 mmol) 4-benzyloxy-1-[2-(4-hydroxymethyl-phenyl)-ethyl]-1H-pyridin-2-one (preparation 2a) in 150 mL MeOH is added 1.50 g Rh/C. The reaction mixture is stirred under a hydrogen atmosphere of 3000 hPa at RT for 20 h. 300 mL MeOH is added and the mixture is heated to reflux. The catalyst is removed by filtration and the solvent is removed almost completely. After cooling to RT, the precipitate is collected and dried in vacuo at 40° C.

후처리

  1. temperaturethe mixture is heated to reflux
  2. customThe catalyst is removed by filtration
  3. customthe solvent is removed almost completely
  4. temperatureAfter cooling to RT
  5. customthe precipitate is collected
  6. customdried in vacuo at 40° C.

출처 및 근거

ORD 기록
ord-c0d06b48fb1c475c8e623074c8bb93b5
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067590B2

반응 노트

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