Phosphorus tribromide → 1-[2-(4-Bromomethyl-phenyl)-ethyl]-4-hydroxy-1H-pyridin-2-one

HRID 564043ノート

反応式

HRID 564043 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][N:5]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16]O)=[CH:12][CH:11]=2)[C:4](=[O:18])[CH:3]=1.P(Br)(Br)[Br:20]>C(Cl)Cl>[Br:20][CH2:16][C:13]1[CH:14]=[CH:15][C:10]([CH2:9][CH2:8][N:5]2[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][C:4]2=[O:18])=[CH:11][CH:12]=1

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 580427304-Hydroxy-1-[2-(4-hydroxymethyl-phenyl)-ethyl]-1H-pyridin-2-one

生成物 1

HCID 580428311-[2-(4-Bromomethyl-phenyl)-ethyl]-4-hydroxy-1H-pyridin-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To 2.45 g (10.0 mmol) 4-hydroxy-1-[2-(4-hydroxymethyl-phenyl)-ethyl]-1H-pyridin-2-one (preparation 2.b) in 25 mL DCM is added 470 μL (5.00 mmol) phosphorus tribromide at 0° C. The mixture is stirred overnight at RT and then poured into ice water. The precipitate is collected, washed with DCM and dried.

後処理

  1. customThe precipitate is collected
  2. washwashed with DCM
  3. customdried

出典と根拠

ORDレコード
ord-a5d4b37fa2c44b0c9aa105a88fa2aff3
出典データセット
uspto-grants-2011_11
特許番号
US08067590B2

反応ノート

読み込み中…