反应详情

To 2.45 g (10.0 mmol) 4-hydroxy-1-[2-(4-hydroxymethyl-phenyl)-ethyl]-1H-pyridin-2-one (preparation 2.b) in 25 mL DCM is added 470 μL (5.00 mmol) phosphorus tribromide at 0° C. The mixture is stirred overnight at RT and then poured into ice water. The precipitate is collected, washed with DCM and dried.

1. customThe precipitate is collected
2. washwashed with DCM
3. customdried