Sodium Hydroxide → HCID 67007765, compound

HRID 564059Notes

Reaction equation

HRID 564059 reaction equation
C[O:2][C:3]([C:5]1[S:6][C:7]([CH2:10][CH2:11][N:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:14][C:13]2=[O:26])=[CH:8][CH:9]=1)=[O:4].[OH-].[Na+]>CO>[CH2:19]([O:18][C:15]1[CH:16]=[CH:17][N:12]([CH2:11][CH2:10][C:7]2[S:6][C:5]([C:3]([OH:4])=[O:2])=[CH:9][CH:8]=2)[C:13](=[O:26])[CH:14]=1)[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 14798Sodium Hydroxide2×HCID 67006628HCID 67006628, compound

Product 1

HCID 67007765HCID 67007765, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 540 mg (1.46 mmol) 5-[2-(4-benzyloxy-2-oxo-2H-pyridin-1-yl)-ethyl]-thiophene-2-carboxylic acid methyl ester (preparation 11b) in 8.0 mL MeOH is added 5.5 mL (5.50 mmol) 1M aqueous sodium hydroxide-solution. The reaction is stirred overnight at RT and additional 3.0 mL (3.00 mmol) 1M aqueous sodium hydroxide-solution is added. The reaction mixture is stirred 4 days at RT and the solvent is evaporated. The residue is acidified with 1M aqueous HCl, the precipitate is collected, washed with water and dried.

Workup

  1. stirringThe reaction mixture is stirred 4 days at RT
  2. customthe solvent is evaporated
  3. customthe precipitate is collected
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-c4d9f2362919411cae91d7b785e4a14f
Source dataset
uspto-grants-2011_11
Patent number
US08067590B2

Reaction notes

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