反应详情

A mixture of 500 mg (2.33 mmol) 4-(benzyl-methyl-amino)-1H-pyridin-2-one (preparation 14b) and 1.52 g (4.67 mmol) cesium carbonate in 2.3 mL of DMF is stirred 15 min at RT and then 1.22 g (4.67 mmol) [4-(2-iodo-ethyl)-phenyl]-methanol (preparation 1b) is added. The mixture is stirred overnight at RT and the solvent is evaporated. The residue is dissolved in MeOH and is purified by reverse HPLC (Waters symmetry, C18; water (0.15% formic acid)/acetonitrile 95:5 to 10:90).

1. stirringThe mixture is stirred overnight at RT
2. customthe solvent is evaporated
3. dissolutionThe residue is dissolved in MeOH
4. customis purified by reverse HPLC (Waters symmetry, C18; water (0.15% formic acid)/acetonitrile 95:5 to 10:90)