Phosphorus tribromide → 4-(Benzyl-methyl-amino)-1-[2-(4-bromomethyl-phenyl)-ethyl]-1H-pyridin-2-one

HRID 564062ノート

反応式

HRID 564062 の反応式
[CH2:1]([N:8]([CH3:26])[C:9]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23]O)=[CH:19][CH:18]=2)[C:11](=[O:25])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Br)(Br)[Br:28]>C(Cl)Cl.C([O-])(O)=O.[Na+].O>[CH2:1]([N:8]([CH3:26])[C:9]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][Br:28])=[CH:19][CH:18]=2)[C:11](=[O:25])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 2

HCID 24614Phosphorus tribromideHCID 670066464-(Benzyl-methyl-amino)-1-[2-(4-hydroxymethyl-phenyl)-ethyl]-1H-pyridin-2-one

生成物 1

HCID 580427254-(Benzyl-methyl-amino)-1-[2-(4-bromomethyl-phenyl)-ethyl]-1H-pyridin-2-one

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6344Dichloromethane溶媒HCID 516892Sodium Bicarbonate溶媒

実験手順

To 280 mg (0.80 mmol, 74% purity) 4-(benzyl-methyl-amino)-1-[2-(4-hydroxymethyl-phenyl)-ethyl]-1H-pyridin-2-one (preparation 14c) in 5.0 mL of DCM is added at 0° C. 53 μL (0.56 mmol) phosphorus tribromide. The mixture is stirred overnight at RT and is diluted with aqueous NaHCO3-solution and water. The layers are separated and the organic phase is dried over MgSO4, filtered and the solvent is removed. The residue is used directly without further purification.

後処理

  1. customThe layers are separated
  2. dry with materialthe organic phase is dried over MgSO4
  3. filtrationfiltered
  4. customthe solvent is removed
  5. customThe residue is used directly without further purification

出典と根拠

ORDレコード
ord-14f2a9664b2b432784a8304f06df9ad4
出典データセット
uspto-grants-2011_11
特許番号
US08067590B2

反応ノート

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