反应详情

To 5.10 g (24.9 mmol) (4-bromo-2-fluoro-phenyl)-methanol in 30 mL DMF is added subsequently 4.06 g (26.1 mmol) tert-butyl-chloro-dimethyl silane, 2.57 g (37.3 mmol) imidazole and 456 mg (3.73 mmol) DMAP. The reaction mixture is stirred overnight at RT and the solvent is evaporated. The residue is diluted with EtOAc, washed five times with water and the combined organic phase is dried over MgSO4, filtered and the solvent is evaporated.

1. customthe solvent is evaporated
2. additionThe residue is diluted with EtOAc
3. washwashed five times with water
4. dry with materialthe combined organic phase is dried over MgSO4
5. filtrationfiltered
6. customthe solvent is evaporated