反应详情

To 2.20 g (7.37 mmol) 4-(tert-butyl-dimethyl-silanyloxymethyl)-3-fluoro-benzoic acid methyl ester (preparation 16c) in 30 mL EtOH is added 12 mL 1 M aqueous NaOH-solution. The mixture is stirred 1 h at RT, additional 4 mL 1 M aqueous NaOH-solution are added and the reaction mixture is stirred an additional hour. The solvent is evaporated, the residue is acidified with 1 M aqueous HCl-solution. The precipitate is collected and dried.

1. stirringthe reaction mixture is stirred an additional hour
2. customThe solvent is evaporated
3. customThe precipitate is collected
4. customdried