HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-[4-(hydroxymethyl)phenyl]ethanone → 2-Bromo-1-(3-fluoro-4-hydroxymethyl-phenyl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-[4-(hydroxymethyl)phenyl]ethanone | HCID 19798053 | — |
| Reactant | Tetra-n-butylammonium tribromide | HCID 23500184 | — |
| Reactant | 1-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-fluoro-phenyl]-ethanone | HCID 131729294 | — |
| Product | 2-Bromo-1-(3-fluoro-4-hydroxymethyl-phenyl)-ethanone | HCID 86623686 | — |
Reaction Steps
2-Bromo-1-(3-fluoro-4-hydroxymethyl-phenyl)-ethanone is prepared following preparation 15a from 280 mg (0.99 mmol) 1-[4-(tert-butyl-dimethyl-silanyloxymethyl)-3-fluoro-phenyl]-ethanone (preparation 16e) and 478 mg (0.99 mmol) tetrabutylammonium-tribromide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067590B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-14bf8311e809461d8ed5f4cb173c7c8c |
| Source note | uspto-grants-2011_11 |