化工社化工社 化学情報印刷レポート · 研究参考用
2-Bromo-1-[4-(hydroxymethyl)phenyl]ethanone → 5-Benzyloxy-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-1-[4-(hydroxymethyl)phenyl]ethanone | HCID 19798053 | — |
| 反応物 | 5-(benzyloxy)pyridazin-3(2H)-one | HCID 59822107 | — |
| 反応物 | 4-Benzyloxy-1-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one | HCID 67006842 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 5-Benzyloxy-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one | HCID 67006537 | — |
反応手順
5-Benzyloxy-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one is prepared following preparation 15b from 5.20 g (25.7 mmol) 5-benzyloxy-2H-pyridazin-3-one (preparation 5c) and 7.70 g (28.6 mmol) 2-bromo-1-(4-hydroxymethyl-phenyl)-ethanone (preparation 15a) using DMSO as solvent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08067590B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-33381a1670784738974bd272d5735584 |
| 出典メモ | uspto-grants-2011_11 |