HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-[4-(hydroxymethyl)phenyl]ethanone → 5-(5-Chloro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-[4-(hydroxymethyl)phenyl]ethanone | HCID 19798053 | — |
| Reactant | 4-Benzyloxy-1-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one | HCID 67006842 | — |
| Reactant | 5-(5-chloro-pyridin-2-ylmethoxy)-2H-pyridazin-3-one | HCID 67007105 | — |
| Product | 5-(5-Chloro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one | HCID 67007851 | — |
Reaction Steps
5-(5-Chloro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one is prepared following preparation 15b from 450 mg (1.89 mmol) 5-(5-chloro-pyridin-2-ylmethoxy)-2H-pyridazin-3-one (preparation 18b) and 477 mg (2.08 mmol) 2-bromo-1-(4-hydroxymethyl-phenyl)-ethanone (preparation 15a).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067590B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-51bfa1126ceb45ff83ed1f1c81582f51 |
| Source note | uspto-grants-2011_11 |