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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 564077Generated: October 27, 2026

(5-Fluoropyridin-2-yl)methanol → 5-(5-Fluoro-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one

https://huagongshe.com/reaction/564077

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(5-Fluoropyridin-2-yl)methanolHCID 24729312—
Reactant5-Hydroxy-2-(2-tetrahydropyranyl)pyridazin-3(2H)-oneHCID 57950355—
Reactant5-(5-Chloro-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-oneHCID 67006504—
Product5-(5-Fluoro-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-oneHCID 58092194—

Reaction Steps

5-(5-Fluoro-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one is prepared following preparation 18a from 2.40 g (12.2 mmol) 5-hydroxy-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one (see preparation 5a) and 1.56 g (12.2 mmol) (5-fluoro-pyridin-2-yl)-methanol

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08067590B2
Source datasetuspto-grants-2011_11
ORD IDord-a63fd859e3df42539cebdaf0d78ae006
Source noteuspto-grants-2011_11