HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Bromo-1-[4-(hydroxymethyl)phenyl]ethanone → 5-(5-Fluoro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Bromo-1-[4-(hydroxymethyl)phenyl]ethanone | HCID 19798053 | — |
| Edukt | 5-((5-fluoropyridin-2-yl)methoxy)pyridazin-3(2H)-one | HCID 58092258 | — |
| Edukt | 4-Benzyloxy-1-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one | HCID 67006842 | — |
| Produkt | 5-(5-Fluoro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one | HCID 67007303 | — |
Reaktionsschritte
5-(5-Fluoro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one is prepared following preparation 15b (with acetonitrile as solvent) from 350 mg (1.58 mmol) 5-(5-fluoro-pyridin-2-ylmethoxy)-2H-pyridazin-3-one (preparation 19b) and 399 mg (1.74 mmol) 2-bromo-1-(4-hydroxymethyl-phenyl)-ethanone (preparation 15a).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08067590B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-e1dc57acda184ebb8af2642fe0b0fd1f |
| Quellennotiz | uspto-grants-2011_11 |