Thionyl Chloride → 2-[2-(4-Chloromethyl-phenyl)-2-oxo-ethyl]-5-(5-fluoro-pyridin-2-ylmethoxy)-2H-pyridazin-3-one

HRID 564080노트

반응식

HRID 564080 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][O:9][C:10]2[CH:15]=[N:14][N:13]([CH2:16][C:17]([C:19]3[CH:24]=[CH:23][C:22]([CH2:25]O)=[CH:21][CH:20]=3)=[O:18])[C:12](=[O:27])[CH:11]=2)=[N:6][CH:7]=1.S(Cl)([Cl:30])=O>C(Cl)Cl.C(OC)(C)(C)C>[Cl:30][CH2:25][C:22]1[CH:23]=[CH:24][C:19]([C:17](=[O:18])[CH2:16][N:13]2[C:12](=[O:27])[CH:11]=[C:10]([O:9][CH2:8][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][N:6]=3)[CH:15]=[N:14]2)=[CH:20][CH:21]=1

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 670073035-(5-Fluoro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one

생성물 1

HCID 580428282-[2-(4-Chloromethyl-phenyl)-2-oxo-ethyl]-5-(5-fluoro-pyridin-2-ylmethoxy)-2H-pyridazin-3-one

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 15413tert-Butyl methyl ether용매

실험 절차

To 400 mg (1.08 mmol) 5-(5-fluoro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one (preparation 19c) in 10 mL DCM is added 0.12 mL (1.62 mmol) thionylchloride at 0° C. The reaction mixture is stirred 2 h at RT and diluted with tert-butylmethylether. The precipitate is collected and dried.

후처리

  1. customThe precipitate is collected
  2. customdried

출처 및 근거

ORD 기록
ord-7c3cd55924db459cbf5438790a7bd04e
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067590B2

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