5-(5-chloro-pyridin-2-ylmethoxy)-2H-pyridazin-3-one → 5-(4-Fluoro-benzyloxy)-2H-pyridazin-3-one

HRID 564091Notes

Reaction equation

HRID 564091 reaction equation
ClC1C=CC(COC2C=NNC(=O)C=2)=NC=1.[F:17][C:18]1[CH:38]=[CH:37][C:21]([CH2:22][O:23][C:24]2[CH:29]=[N:28][N:27](C3CCCCO3)[C:26](=[O:36])[CH:25]=2)=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:22][O:23][C:24]2[CH:29]=[N:28][NH:27][C:26](=[O:36])[CH:25]=2)=[CH:37][CH:38]=1

Participants

3

Reactant 2

HCID 670071055-(5-chloro-pyridin-2-ylmethoxy)-2H-pyridazin-3-oneHCID 670074195-(4-Fluoro-benzyloxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one

Product 1

HCID 580426945-(4-Fluoro-benzyloxy)-2H-pyridazin-3-one

Procedure

5-(4-Fluoro-benzyloxy)-2H-pyridazin-3-one is prepared following preparation 18b from 10.5 g (34.5 mmol) 5-(4-fluoro-benzyloxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one (preparation 26a).

Sources & evidence

ORD record
ord-77d6f44d40604b07bfb1fb8313907f39
Source dataset
uspto-grants-2011_11
Patent number
US08067590B2

Reaction notes

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