5-(5-chloro-pyridin-2-ylmethoxy)-2H-pyridazin-3-one → 5-(Pyridin-2-ylmethoxy)-2H-pyridazin-3-one

HRID 564093Notes

Reaction equation

HRID 564093 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([CH2:8][O:9][C:10]2[CH:15]=[N:14][NH:13][C:12](=[O:16])[CH:11]=2)=[N:6][CH:7]=1.N1C=CC=CC=1COC1C=NN(C2CCCCO2)C(=O)C=1>>[N:6]1[CH:7]=[CH:2][CH:3]=[CH:4][C:5]=1[CH2:8][O:9][C:10]1[CH:15]=[N:14][NH:13][C:12](=[O:16])[CH:11]=1

Participants

3

Reactant 2

HCID 670071055-(5-chloro-pyridin-2-ylmethoxy)-2H-pyridazin-3-oneHCID 670072905-(Pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one

Product 1

HCID 580428595-(Pyridin-2-ylmethoxy)-2H-pyridazin-3-one

Procedure

5-(Pyridin-2-ylmethoxy)-2H-pyridazin-3-one is prepared following preparation 18b from 2.40 g (8.35 mmol) 5-(pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one (preparation 27a).

Sources & evidence

ORD record
ord-67576d0edac94359a247b250fe603650
Source dataset
uspto-grants-2011_11
Patent number
US08067590B2

Reaction notes

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