化工社化工社 化学情報印刷レポート · 研究参考用
5-(benzyloxy)pyridazin-3(2H)-one → 5-Benzyloxy-2-{2-oxo-2-[2-(2,2,2-trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl]-ethyl}-2H-pyridazin-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(benzyloxy)pyridazin-3(2H)-one | HCID 59822107 | — |
| 反応物 | 4-Benzyloxy-1-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one | HCID 67006842 | — |
| 反応物 | 1-[7-(2-chloro-acetyl)-3,4-dihydro-1H-isoquinolin-2-yl]-2,2,2-trifluoro-ethanone | HCID 86623688 | — |
| 生成物 | 5-Benzyloxy-2-{2-oxo-2-[2-(2,2,2-trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl]-ethyl}-2H-pyridazin-3-one | HCID 58042795 | — |
反応手順
5-Benzyloxy-2-{2-oxo-2-[2-(2,2,2-trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl]-ethyl}-2H-pyridazin-3-one is prepared following preparation 15b (DMSO as solvent; purification via HPLC) from 3.00 g (14.8 mmol) 5-benzyloxy-2H-pyridazin-3-one (preparation 5c) and 4.54 g (14.8 mmol) 1-[7-(2-chloro-acetyl)-3,4-dihydro-1H-isoquinolin-2-yl]-2,2,2-trifluoro-ethanone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08067590B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-10b81e98925947fc9cead684fc4fdfcb |
| 出典メモ | uspto-grants-2011_11 |