Pyrrolidine → HCID 58042807, compound

Participants

Reaction Steps

To 120 mg (0.29 mmol) 1-[2-(4-bromomethyl-phenyl)-ethyl]-4-(3-fluoro-benzyloxy)-1H-pyridin-2-one (example 8.1b) in 2.0 mL DMF is added at RT 95 μL (1.15 mmol) pyrrolidine. The reaction mixture is stirred overnight at RT and is directly transferred to a reverse HPLC for purification (Waters symmetry; water (0.15% formic acid)/acetonitrile 95:5 to 10:90).

Provenance & Evidence