HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 58042759, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Acetamidopiperidine | HCID 1445156 | — |
| Reactant | 1-[2-(4-bromomethyl-phenyl)ethyl]-4-(3-fluoro-benzyloxy)-1H-pyridin-2-one | HCID 67006807 | — |
| Product | HCID 58042759 | HCID 58042759 | — |
Reaction Steps
N-[1-(4-{2-[4-(3-Fluoro-benzyloxy)-2-oxo-2H-pyridin-1-yl]-ethyl}-benzyl)-piperidin-4-yl]-acetamide is prepared as example 8.1c from 120 mg (0.29 mmol) 1-[2-(4-bromomethyl-phenyl)ethyl]-4-(3-fluoro-benzyloxy)-1H-pyridin-2-one (example 8.1b), 61 mg (0.43 mmol) N-piperidin-4-yl-acetamide and 126 μL (0.72 mmol) N-ethyl-diisopropylamine as base.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067590B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-0d7fb338cd7043dbbba89f1508bddbb1 |
| Source note | uspto-grants-2011_11 |