Triethylamine → HCID 58042804, compound

Participants

Reaction Steps

N-[1-(4-{2-[2-Oxo-4-(pyridin-4-ylmethoxy)-2H-pyridin-1-yl]-ethyl}-benzyl)-piperidin-4-yl]-acetamide is prepared as example 10.1b from 80 mg (0.24 mmol) 1-[2-(4-hydroxymethylphenyl)-ethyl]-4-(pyridin-4-ylmethoxy)-1H-pyridin-2-one (example 10.1a), 101 mg (0.71 mmol) N-piperidin-4-yl-acetamide, 99 μL triethylamine (0.71 mmol) and subsequently 37 μL (0.48 mmol) methanesulfonyl chloride. The product is purified via reverse HPLC chromatography (Zorbax stable bond, C18; water (0.1% formic acid)/acetonitrile (0.1% formic acid) 95:5 to 10:90).

Provenance & Evidence