HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl methyl ether → HCID 67006912, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | 1-[2-(4-Hydroxymethyl-phenyl)-ethyl]-4-(3-methyl-pyridin-2-ylmethoxy)-1H-pyridin-2-one | HCID 67006941 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67006912 | HCID 67006912 | — |
Reaction Steps
To 280 mg (0.80 mmol) 1-[2-(4-hydroxymethyl-phenyl)-ethyl]-4-(3-methyl-pyridin-2-ylmethoxy)-1H-pyridin-2-one (example 14.1a) in 8.0 mL of DCM is added 75 μL (0.80 mmol) phosphorus tribromide. The mixture is stirred 2 h at RT and tert-butylmethylether is added. The formed precipitate is collected, washed with tert-butylmethylether and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067590B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-82bcde44552d4835ab885742d7e6e7c0 |
| Source note | uspto-grants-2011_11 |