4-Acetamidopiperidine → HCID 58042833, compound

HRID 564153Notes

Reaction equation

HRID 564153 reaction equation
C1CN(C(CNCC2C=CC3OCOC=3C=2)=O)CC1.Br[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][N:30]2[CH:35]=[CH:34][C:33]([O:36][CH2:37][C:38]3[N:39]=[N:40][CH:41]=[CH:42][CH:43]=3)=[CH:32][C:31]2=[O:44])=[CH:24][CH:23]=1.[NH:45]1[CH2:50][CH2:49][CH:48]([NH:51][C:52](=[O:54])[CH3:53])[CH2:47][CH2:46]1>>[O:44]=[C:31]1[CH:32]=[C:33]([O:36][CH2:37][C:38]2[N:39]=[N:40][CH:41]=[CH:42][CH:43]=2)[CH:34]=[CH:35][N:30]1[CH2:29][CH2:28][C:25]1[CH:26]=[CH:27][C:22]([CH2:21][N:45]2[CH2:50][CH2:49][CH:48]([NH:51][C:52](=[O:54])[CH3:53])[CH2:47][CH2:46]2)=[CH:23][CH:24]=1

Participants

4

Reactant 3

HCID 14451564-AcetamidopiperidineHCID 11277009HCID 11277009, compoundHCID 67006824HCID 67006824, compound

Product 1

HCID 58042833HCID 58042833, compound

Procedure

N-[1-(4-{2-[2-Oxo-4-(pyridazin-3-ylmethoxy)-2H-pyridin-1-yl]-ethyl}-benzyl)-piperidin-4-yl]-acetamide is prepared as example 15.1c from 110 mg (0.28 mmol) 1-[2-(4-bromomethylphenyl)-ethyl]-4-(pyridazin-3-ylmethoxy)-1H-pyridin-2-one (example 15.1b) and 156 mg (1.10 mmol) N-piperidin-4-yl-acetamide.

Sources & evidence

ORD record
ord-133ebdcdff5446cbb9436411f9bde908
Source dataset
uspto-grants-2011_11
Patent number
US08067590B2

Reaction notes

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