反应详情

To 350 mg (0.72 mmol) 4-(5-fluoro-pyridin-2-ylmethoxy)-1-{2-[3-(2,2,2-trifluoro-acetyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-ethyl}-1H-pyridin-2-one (preparation 23.10a) in 10 mL MeOH is added 1.1 mL (1.10 mmol) 1 M aqueous NaOH-solution. The reaction mixture is stirred overnight at RT. After filtration is the residue purified via reverse HPLC chromatography (Waters Xbridge; water (0.3% NH4OH)/acetonitrile (0.3% NH4OH) 95:5 to 5:95).

1. filtrationAfter filtration
2. custompurified via reverse HPLC chromatography (Waters Xbridge; water (0.3% NH4OH)/acetonitrile (0.3% NH4OH) 95:5 to 5:95)