Formaldehyde → HCID 58042837, compound

Participants

Reaction Steps

To 60 mg (0.13 mmol) 4-(5-bromo-pyridin-2-ylmethoxy)-1-[2-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-ethyl]-1H-pyridin-2-one (example 23.15) in 5.0 mL THF is added 43 μL (0.53 mmol) aqueous 37% formaldehyde solution and 56 mg (0.26 mmol) sodium triacetoxy-borohydride. The mixture is acidified with pH 5 buffer solution and is stirred 48 h at RT. After filtration is the residue purified via reverse HPLC chromatography (Waters Xbridge; water (0.30% NH4OH)/acetonitrile (0.30% NH4OH) 95:5 to 5:95).

Provenance & Evidence