4-(Pyridin-2-ylmethoxy)pyridin-2(1H)-one → 7-{2-[2-Oxo-4-(pyridin-2-ylmethoxy)-2H-pyridin-1-yl]-ethyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

HRID 564184Notes

Reaction equation

HRID 564184 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][O:8][C:9]1[CH:14]=[CH:13][NH:12][C:11](=[O:15])[CH:10]=1.[C:16]([O:20][C:21]([N:23]1[CH2:32][CH2:31][C:30]2[C:25](=[CH:26][C:27]([CH2:33][CH2:34]OS(C3C=CC(C)=CC=3)(=O)=O)=[CH:28][CH:29]=2)[CH2:24]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([N:23]1[CH2:32][CH2:31][C:30]2[C:25](=[CH:26][C:27]([CH2:33][CH2:34][N:12]3[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=4)=[CH:10][C:11]3=[O:15])=[CH:28][CH:29]=2)[CH2:24]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 579502834-(Pyridin-2-ylmethoxy)pyridin-2(1H)-oneHCID 580427197-[2-(toluene-4-sulfonyloxy)ethyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Product 1

HCID 670066487-{2-[2-Oxo-4-(pyridin-2-ylmethoxy)-2H-pyridin-1-yl]-ethyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Procedure

7-{2-[2-Oxo-4-(pyridin-2-ylmethoxy)-2H-pyridin-1-yl]-ethyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester is prepared following example 24.1 from 530 mg (2.23 mmol) 4-(pyridin-2-ylmethoxy)-1H-pyridin-2-one (preparation 22.4) and 1.06 g (2.45 mmol) 7-[2-(toluene-4-sulfonyloxy)-ethyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (preparation 7).

Sources & evidence

ORD record
ord-6fed6184df9a4eb59d20494a3ea1f4da
Source dataset
uspto-grants-2011_11
Patent number
US08067590B2

Reaction notes

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