4-Acetamidopiperidine → HCID 58042796, compound

HRID 564192Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][C:17]2[S:18][C:19]([CH2:22]O)=[CH:20][CH:21]=2)[C:11](=[O:24])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:25]1[CH2:30][CH2:29][CH:28]([NH:31][C:32](=[O:34])[CH3:33])[CH2:27][CH2:26]1>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][C:17]2[S:18][C:19]([CH2:22][N:25]3[CH2:30][CH2:29][CH:28]([NH:31][C:32](=[O:34])[CH3:33])[CH2:27][CH2:26]3)=[CH:20][CH:21]=2)[C:11](=[O:24])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 14451564-Acetamidopiperidine

HCID 58042873HCID 58042873, compound

Product 1

HCID 58042796HCID 58042796, compound

Procedure

N-(1-{5-[2-(4-Benzyloxy-2-oxo-2H-pyridin-1-yl)-ethyl]-thiophen-2-ylmethyl}-piperidin-4-yl)acetamide is prepared as example 28.1 from 70 mg (0.21 mmol) 4-benzyloxy-1-[2-(5-hydroxymethyl-thiophen-2-yl)-ethyl]-1H-pyridin-2-one (preparation 11d) and 58 mg (0.41 mmol) N-piperidin-4-yl-acetamide.

Sources & evidence

ORD record: ord-a5baf69cc51c44ddbcb0f9066cae17a3
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08067590B2

Reaction notes

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