Sodium periodate → HCID 58042797, compound

Participants

Reaction Steps

To 200 mg (0.50 mmol) 4-benzyloxy-1-[2-(4-pyrrolidin-1-ylmethyl-phenyl)-allyl]-1H-pyridin-2-one (example 26.1) in 6.0 mL acetonitrile is added at RT subsequently a solution of 4 mg (0.02 mmol) ruthenium(III)-trichloride hydrate in 1.0 mL water and then 214 mg (1.00 mmol) sodium metaperiodate in small portions. The reaction mixture is stirred 4 h at RT and is diluted with aqueous 10% sodium thiosulfate solution. The layers are separated and the aqueous phase is extracted with DCM. The combined organic phase is dried over MgSO4, filtered and the solvent is evaporated. The residue is purified via reverse HPLC chromatography (Waters xbridge; water (15% NH4OH)/acetonitrile (15% NH4OH) 95:5 to 5:95).

Provenance & Evidence