Piperidin-4-ol → 4-Benzyloxy-1-{2-[4-(4-hydroxy-piperidin-1-ylmethyl)-phenyl]-2-oxo-ethyl}-1H-pyridin-2-one

Participants

Reaction Steps

To 400 mg (0.97 mmol) 4-benzyloxy-1-[2-(4-bromomethyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one (preparation 15c) in 5.0 mL of DMF is added 393 mg (3.88 mmol) 4-hydroxypiperidine. The reaction mixture is stirred 1 h at RT and is directly purified by HPLC (Waters Symmetry, C18; water (0.1% formic acid)/acetonitrile (0.1% formic acid) 95:5 to 0:100).

Provenance & Evidence