tert-Butyl piperazine-1-carboxylate → 4-(1-{4-[2-(4-Benzyloxy-6-oxo-6H-pyridazin-1-yl)-acetyl]-phenyl}-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

HRID 564212Notes

Reaction equation

HRID 564212 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[N:13][N:12]([CH2:15][C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH:24](Br)[CH3:25])=[CH:20][CH:19]=2)=[O:17])[C:11](=[O:27])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:28]([O:32][C:33]([N:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1)=[O:34])([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33]([N:35]1[CH2:40][CH2:39][N:38]([CH:24]([C:21]2[CH:22]=[CH:23][C:18]([C:16](=[O:17])[CH2:15][N:12]3[C:11](=[O:27])[CH:10]=[C:9]([O:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[CH:14]=[N:13]3)=[CH:19][CH:20]=2)[CH3:25])[CH2:37][CH2:36]1)=[O:34])([CH3:31])([CH3:29])[CH3:30]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 58042755HCID 58042755, compound

Product 1

HCID 670069934-(1-{4-[2-(4-Benzyloxy-6-oxo-6H-pyridazin-1-yl)-acetyl]-phenyl}-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

Procedure

4-(1-{4-[2-(4-Benzyloxy-6-oxo-6H-pyridazin-1-yl)-acetyl]-phenyl}-ethyl)-piperazine-1-carboxylic acid tert-butyl ester is prepared following example 1.1b from 200 mg (0.47 mmol) 5-benzyloxy-2-{2-[4-(1-bromo-ethyl)-phenyl]-2-oxo-ethyl}-2H-pyridazin-3-one (preparation 30c) and 262 mg (1.40 mmol) piperazine-1-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record
ord-58a204e2f5604b4c8c958e938782b30a
Source dataset
uspto-grants-2011_11
Patent number
US08067590B2

Reaction notes

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