HCID 66758835, compound → HCID 66759222, compound

Participants

Reaction Steps

A solution of EXAMPLE 28E (0.21 g) in TFA (10 mL) was stirred at ambient temperature overnight and concentrated. The concentrate was purified by HPLC (Zorbax, C-18, Mobile phase A: 0.1% TFA in water; B: 0.1% TFA in acetonitrile; 0-100% gradient). 1H NMR (DMSO-d6) δ 1.62-1.76 (m, 1H), 1.84-1.96 (m, 2H), 2.00-2.08 (m, 1H), 2.10-2.20 (m, 1H), 2.19-2.28 (m, 1H), 3.06-3.13 (m, 1H), 3.34-3.47 (m, 1H), 4.36-4.50 (m, 1H), 7.02 (s, 1H), 7.28 (t, J=7.9 Hz, 1H), 7.38 (d, J=4.0 Hz, 1H), 7.65 (d, J=7.0 Hz, 1H), 7.81 (d, J=4.0 Hz, 1H), 7.98 (d, J=7.3 Hz, 1H), 9.40 (s, 1H), 9.50 (s, 1H), 10.10 (s, 1H).

Provenance & Evidence